Abacwaningi bathole ukwelashwa okusha okungaba khona kwesifo i-Alzheimer's ngendlela yokuthiI-EGCG, inhlanganisela etholakala etiyeni eliluhlaza. Ucwaningo olwanyatheliswa kuyi-Journal of Biological Chemistry luthole ukuthiI-EGCGkungaphazamisa ukwakheka kwama-amyloid plaque, okuwuphawu lwesifo i-Alzheimer's. Abacwaningi benza izivivinyo kumagundane futhi bathola ukuthiI-EGCGkunciphise ukukhiqizwa kwamaphrotheni e-amyloid beta, aziwa ngokunqwabelana futhi akhe ama-plaque ebuchosheni beziguli ze-Alzheimer's. Lokhu okutholakele kusikisela ukuthiI-EGCGkungaba umuntu othembisayo ekuthuthukisweni kwezindlela zokwelapha ezintsha zesifo i-Alzheimer's.
Isayensi EsemuvaI-EGCG: Ukuhlola Izinzuzo zayo Zezempilo kanye Nezicelo Ezingaba Khona :
Ucwaningo luphinde lwathola ukuthiI-EGCGkungasiza ukuvikela amangqamuzana obuchopho emiphumeleni enobuthi yama-amyloid beta amaprotheni. Lokhu kubalulekile ngoba ukufa kwamangqamuzana obuchopho kuyisici esikhulu ekuqhubekeleni phambili kwesifo i-Alzheimer's. Ngokuvimbela imiphumela enobuthi yama-amyloid beta amaprotheni,I-EGCGingase ibambezele ukuqhubeka kwesifo futhi ilondoloze ukusebenza kwengqondo ezigulini.
Ngaphezu kwezinzuzo zayo ezingaba khona zesifo i-Alzheimer's,I-EGCGiphinde yacwaningwa ngezindawo zayo zokulwa nomdlavuza. Ucwaningo luye lwabonisa lokhoI-EGCGingavimbela ukukhula kwamangqamuzana omdlavuza futhi yenze i-apoptosis, noma ukufa kwamangqamuzana ahleliwe, kumaseli omdlavuza. Lokhu kusikisela ukuthiI-EGCGkungaba yithuluzi elibalulekile ekwakhiweni kokwelashwa okusha komdlavuza.
Ngaphezu kwalokho,I-EGCGitholwe inezindawo zokulwa nokuvuvukala kanye ne-antioxidant, engayenza ibe nenzuzo ezinhlobonhlobo zezimo zezempilo. Ucwaningo luye lwabonisa lokhoI-EGCGingasiza ekunciphiseni ukuvuvukala emzimbeni futhi ivikele amangqamuzana emonakalweni we-oxidative. Lokhu kungaba nomthelela ezimeni ezifana nesifo senhliziyo, isifo sikashukela, nesifo samathambo.
Ukutholakala kweI-EGCGIzinzuzo ezingaba khona zesifo i-Alzheimer's kanye nezakhiwo zayo ezaziwayo zokulwa nomdlavuza, ukulwa nokuvuvukala, kanye ne-antioxidant ziyenza ibe yindawo ethokozisayo yocwaningo. Kuzodingeka ezinye izifundo ukuze uqonde ngokugcwele izindlela zokwenzaI-EGCGkanye nokunquma amandla ayo njenge-ejenti yokwelapha ezimweni ezehlukene zempilo. Nokho, okutholakele kuze kube manje kusikisela lokhoI-EGCGingaba nesithembiso sokuthuthukiswa kokwelashwa okusha kwesifo i-Alzheimer kanye nezinye izimo zezempilo.
Isikhathi sokuthumela: Jul-29-2024
