• YiniI-Tetrahydrocurcumin ?
I-Rhizoma Curcumae Longae iyi-rhizoma eyomile ye-Curcumae Longae L. Isetshenziswa kakhulu njengombala wokudla kanye nephunga elimnandi. Ukwakheka kwayo kwamakhemikhali ikakhulukazi kuhlanganisa i-curcumin namafutha aguquguqukayo, ngaphandle kwama-saccharides nama-sterol. I-Curcumin (CUR), njenge-polyphenol yemvelo esitshalweni se-curcuma, iboniswe ukuthi inemiphumela ehlukahlukene ye-pharmacological, kuhlanganise ne-anti-inflammatory, i-antioxidant, i-oxygen free radical elimination, ukuvikelwa kwesibindi, i-anti-fibrosis, umsebenzi wokulwa ne-tumor kanye nokuvimbela. Isifo i-Alzheimer's (AD).
I-Curcumin iguqulwa ngokushesha emzimbeni ibe yi-glucuronic acid conjugates, i-sulfuric acid conjugates, i-dihydrocurcumin, i-tetrahydrocurcumin, ne-hexahydrocurcumin, yona iguqulwa ibe yi-tetrahydrocurcumin. Ucwaningo lokuhlola luye lwaqinisekisa ukuthi i-curcumin inokuzinza okubi (bona i-photodecomposition), ukuncibilika okuncane kwamanzi kanye ne-bioavailability ephansi. Ngakho-ke, ingxenye yayo eyinhloko ye-metabolic i-tetrahydrocurcumin emzimbeni isiphenduke indawo yokucwaninga ekhaya naphesheya eminyakeni yamuva.
I-Tetrahydrocurcumin(i-THC), njenge-metabolite esebenzayo kakhulu futhi eyinhloko ye-curcumin ekhiqizwa ngesikhathi se-metabolism ku-vivo, ingahlukaniswa ne-cytoplasm yamathumbu amancane nesibindi ngemva kokuphathwa kwe-curcumin kumuntu noma igundane. Ifomula yamangqamuzana ithi C21H26O6, isisindo semolekyuli singu-372.2, ukuminyana ngu-1.222, futhi indawo yokuncibilika ingu-95℃-97℃.
• Yiziphi Izinzuzo ZazoI-TetrahydrocurcuminEkunakekelweni Kwesikhumba?
1. Umphumela ekukhiqizeni i-melanin
I-Tetrahydrocurcumin inganciphisa okuqukethwe kwe-melanin kumaseli e-B16F10. Lapho ukugxila okuhambisanayo kwe-tetrahydrocurcumin (25, 50, 100, 200μmol/L) kunikezwa, okuqukethwe kwe-melanin kwehle kusuka ku-100% kuya ku-74.34%, 80.14%, 34.37%, 21.40%, ngokulandelana.
I-Tetrahydrocurcumin ingavimbela umsebenzi we-tyrosinase kumaseli e-B16F10. Lapho ukuhlushwa okuhambisanayo kwe-tetrahydrocurcumin (100 kanye ne-200μmol/L) kunikezwa kumaseli, umsebenzi we-intracellular tyrosinase wehla waba ngu-84.51% no-83.38%, ngokulandelana.
2. Anti-photoaging
Sicela ubone umdwebo wegundane ngezansi: Ctrl (control), UV (UVA + UVB), iTHC (UVA + UVB + THC THC100 mg/kg, encibilike ku-0.5% sodium carboxymethyl cellulose). Izithombe zesikhumba ngemuva kwamagundane e-KM emasontweni ayi-10 ngemuva kokwelashwa okuqokiwe kwe-THC kanye nemisebe ye-UVA. Amaqembu ahlukene anemisebe eguquguqukayo ye-UVA elingana nokuguga ahlolwe umphumela we-Bissett. Amanani ethulwayo awukuchezuka okujwayelekile okumaphakathi (N = 12/ iqembu). *P<0.05, **P
Kusukela ekubukeni, uma kuqhathaniswa neqembu elijwayelekile lokulawula, isikhumba seqembu lokulawula imodeli sasinobukhazikhazi, i-erythema ebonakalayo, izilonda, imibimbi ijule futhi iqiniswe, ihambisana nezinguquko ezifana nesikhumba, ebonisa into evamile yokuthwebula izithombe. Uma kuqhathaniswa neqembu lokulawula imodeli, izinga lomonakalo wei-tetrahydrocurcuminIqembu le-100 mg/kg laliphansi kakhulu kunalelo leqembu lokulawula imodeli, futhi akukho utwayi ne-erythema etholakala esikhumbeni, kwabonakala kuphela umbala omncane kanye nemibimbi emihle.
3. I-antioxidant
I-Tetrahydrocurcumin ingakhuphula izinga le-SOD, yehlise izinga le-LDH futhi ikhulise izinga le-GSH-PX kumaseli e-HaCaT.
Ukususa ama-radicals wamahhala we-DPPH
Ii-tetrahydrocurcuminIsixazululo sihlanjululwe ngo-10, 50, 80, 100, 200, 400, 800, 1600 izikhathi ngokulandelana, futhi isisombululo sesampula sasixutshwe kahle nesisombululo se-DPPH esingu-0.1mmol/L ngesilinganiso esingu-1:5. Ngemuva kokusabela ekamelweni lokushisa kwe-30min, inani lokumunca linqunywe ku-517nm. Umphumela uboniswa emfanekisweni:
4. Vimbela ukuvuvukala kwesikhumba
Ucwaningo lokuhlola lubonise ukuthi ukuphulukiswa kwesilonda kwamagundane kwaqashelwa ngokuqhubekayo izinsuku ezingu-14, lapho ijeli ye-THC-SLNS isetshenziswa ngokulandelana, isivinini sokupholisa isilonda kanye nomphumela we-THC nokulawula okuhle kwakushesha futhi kungcono, ukuhleleka kokwehla kwakuyijeli ye-THC-SLNS. >
I-THC >Ukulawula okuhle.
Ngezansi kunezithombe ezimele imodeli yegundane elisikiwe elisikiwe kanye nokubonwa kwe-histopathological, i-A1 ne-A6 ekhombisa isikhumba esijwayelekile, i-A2 ne-A7 ekhombisa ijeli ye-THC SLN, i-A3 ne-A8 ekhombisa izilawuli ezinhle, i-A4 ne-A9 ekhombisa ijeli yeTHC, kanye ne-A5 ne-A10 ekhombisa okuqinile okungenalutho. i-lipid nanoparticles (SLN), ngokulandelana.
• Isicelo SeI-TetrahydrocurcuminKwezimonyo
1.Imikhiqizo yokunakekelwa kwesikhumba:
Imikhiqizo Yokuguga:Isetshenziswa kuma-anti-aging creams nama-serum ukusiza ukunciphisa imibimbi nemigqa emihle futhi kuthuthukise ukunwebeka kwesikhumba.
Imikhiqizo emhlophe:Kwengezwe kuzinto ezimhlophe namakhilimu ukusiza ukuthuthukisa ithoni yesikhumba engalingani namabala.
2.Imikhiqizo eqeda ukuvuvukala:
Isetshenziswa emikhiqizweni yokunakekelwa kwesikhumba ebucayi efana nokhilimu opholile kanye nokulungisa ukunciphisa ububomvu nokucasuka.
3.Imikhiqizo yokuhlanza:
Yengeza kuzinto zokuhlanza nama-exfoliants ukusiza ukuhlanza isikhumba futhi unikeze izinzuzo zokulwa namagciwane ukuvimbela izinduna.
4.Imikhiqizo yokuvikela ilanga:
Isebenza njenge-antioxidant yokuthuthukisa ukusebenza kwe-sunscreen kanye nokuvikela isikhumba emisebeni ye-UV.
5.Imaski Yobuso:
Isetshenziswa kumaski obuso ahlukahlukene ukunikeza ukudla okujulile nokulungisa, ukuthuthukisa ukuthungwa kwesikhumba.
I-Tetrahydrocurcuminisetshenziswa kakhulu kuzimonyo, ukumboza ukunakekelwa kwesikhumba, ukuhlanza, ukuvikela ilanga neminye imikhakha. Ithandwa ngenxa yemiphumela yayo ye-antioxidant, anti-inflammatory kanye ne-whitening.
Isikhathi sokuthumela: Oct-10-2024
