Bacopa monnieri, eyaziwa nangokuthi i-brahmi ngesi-Sanskrit kanye ne-brain tonic ngesiNgisi, isitshalo se-Ayurvedic esivame ukusetshenziswa. Ukubuyekezwa okusha kwesayensi kuthi i-Indian Ayurvedic herb Bacopa monnieri ikhonjisiwe ukusiza ukuvimbela isifo i-Alzheimer's (AD). Ukubuyekezwa, okushicilelwe kujenali ye-Science Drug Target Insights, kwenziwa ithimba labacwaningi baseMalaysia abavela eNyuvesi yase-Taylor e-United States futhi bahlola imiphumela yezempilo yama-bacosides, ingxenye ye-bioactive yalesi sitshalo.
Ecaphuna izifundo ezimbili ezenziwa ngo-2011, abacwaningi bathi ama-bacosides angase avikele ubuchopho emonakalweni we-oxidative kanye nokwehla kwengqondo okuhlobene neminyaka ngokusebenzisa izindlela eziningi. Njenge-non-polar glycoside, ama-bacosides angakwazi ukweqa umgoqo wegazi nobuchopho ngokusakazwa okulula kwe-lipid-mediated passive. Ngokusekelwe ocwaningweni lwangaphambilini, abacwaningi bathi ama-bacosides angase futhi athuthukise umsebenzi wokuqonda ngenxa yezindawo zawo zokulahla ama-radical mahhala.
Ezinye izinzuzo zezempilo zeama-bacosideskufaka phakathi ukuvikela ama-neuron kubuthi obubangelwa i-Aβ, i-peptide edlala indima ebalulekile ku-pathogenesis ye-AD ngoba ingabuthana ibe ama-amyloid fibrils angancibiliki. Lokhu kubuyekezwa kuveza ukusetshenziswa okuphumelelayo kwe-Bacopa monnieri ekusetshenzisweni kwengqondo kanye ne-neuroprotective, futhi ama-phytoconstituents ayo angasetshenziselwa ukuthuthukiswa kwemithi emisha.Izitshalo eziningi zendabuko ziqukethe inhlanganisela eyinkimbinkimbi yezinhlanganisela ezinemisebenzi ehlukahlukene yezokwelapha kanye ne-biological, ikakhulukazi i-Bacopa monnieri, esetshenziswayo. njengemithi yesintu kanye nasekuthuthukisweni kwemikhiqizo elwa nokuguga.
● Izinzuzo Eziyisithupha ZeBacopa Monnieri
1.Ithuthukisa Inkumbulo Nokuqonda
I-Bacopa inezinzuzo eziningi ezihehayo, kodwa cishe yaziwa kakhulu ngekhono layo lokuthuthukisa inkumbulo nokuqonda. Indlela yokuqala eyenziwa ngayoI-Bacopakuthuthukisa inkumbulo futhi ukuqonda kungokuxhumana okuthuthukisiwe kwe-synaptic. Ngokuqondile, isitshalo sikhuthaza ukukhula nokwanda kwama-dendrites, okuthuthukisa ukusayinda kwezinzwa.
Qaphela: Ama-dendrites ayizandiso zamaseli ezinzwa ezinjengegatsha ezithola amasignali angenayo, ngakho ukuqinisa lezi “zintambo” zokuxhumana kwesistimu yezinzwa ekugcineni kuthuthukisa ukusebenza kwengqondo.
Ucwaningo luye lwathola ukuthi i-Bacoside-A ivuselela amangqamuzana ezinzwa, yenze ama-synapses amukele kakhudlwana ama-nerve impulses angenayo. I-Bacopa iye yaboniswa futhi ukuthuthukisa inkumbulo nokuqonda ngokuvuselela umsebenzi we-hippocampal ngokwandisa umsebenzi we-protein kinase emzimbeni, oguqula izindlela ezihlukahlukene zamaselula.
Njengoba i-hippocampus ibalulekile cishe kuyo yonke imisebenzi yengqondo, abacwaningi bakholelwa ukuthi lena enye yezindlela eziyinhloko i-Bacopa ethuthukisa ngayo amandla obuchopho.
Ezinye izifundo zibonise ukuthi ukwesekwa kwansuku zonke ngeBacopa monnieri(ngemithamo ye-300-640 mg ngosuku) ingathuthuka:
Inkumbulo yokusebenza
Inkumbulo yendawo
Inkumbulo equlekile
Ukunaka
Izinga lokufunda
Ukuqinisa inkumbulo
Umsebenzi wokukhumbula ubambezelekile
Ukukhumbula izwi
Inkumbulo ebonakalayo
2.Yehlisa Ukucindezeleka Nokukhathazeka
Kungakhathaliseki ukuthi kungokwezimali, kwezenhlalo, ngokomzimba, ngokwengqondo, noma ngokomzwelo, ukucindezeleka kuyindaba ehamba phambili ekuphileni kwabantu abaningi. Manje kunanini ngaphambili, abantu babheke ukubaleka nganoma iyiphi indlela edingekayo, kuhlanganise nezidakamizwa notshwala. Nokho, izinto ezifana nezidakamizwa notshwala zingaba nemiphumela emibi engqondweni nasemzimbeni womuntu.
Ungase ube nentshisekelo yokwazi lokhoI-Bacopainomlando omude wokusetshenziswa njenge-tonic yesistimu yezinzwa ukukhulula imizwa yokukhathazeka, ukukhathazeka, nokucindezeleka.Lokhu kubangelwa izakhiwo ze-adapogenic ze-Bacopa, ezithuthukisa ikhono lomzimba wethu lokubhekana, ukuxhumana, nokululama ekucindezelekeni (ngokwengqondo, ngokomzimba. , kanye nemizwa). I-Bacopa isebenzisa lezi zici eziguquguqukayo ngokwengxenye ngenxa yokulawula kwayo ama-neurotransmitters, kodwa lesi sitshalo sasendulo sithinta namazinga e-cortisol.
Njengoba kungenzeka uyazi, i-cortisol iyi-hormone yokucindezeleka eyinhloko yomzimba. Ukucindezeleka okungapheli kanye namazinga e-cortisol aphakeme angalimaza ubuchopho bakho.Eqinisweni, ososayensi bezinzwa bathole ukuthi ukucindezeleka okungapheli kungabangela izinguquko zesikhathi eside ekwakhiweni kobuchopho nokusebenza, okuholela ekukhulumeni ngokweqile kwamaprotheni athile alimaza izinzwa.
Ukucindezeleka okungapheli kuholela ekulimaleni kwe-oxidative kuma-neurons, okungaba nemiphumela emibi ehlukahlukene, okuhlanganisa:
Ukulahlekelwa inkumbulo
Ukufa kwe-Neuron cell
Ukuthathwa kwezinqumo okuphazamisekile
I-Atrophy yesisindo sobuchopho.
I-Bacopa monnieri inezinto ezinamandla zokudambisa ingcindezi, i-neuroprotective. Ucwaningo lwabantu lubhale imiphumela ye-adapogenic ye-Bacopa monnieri, okuhlanganisa nokunciphisa i-cortisol. I-cortisol ephansi iholela ekunciphiseni imizwa yokucindezeleka, engakwazi ukuthuthukisa isimo sengqondo kuphela, kodwa futhi yandise ukugxila nokukhiqiza. Ngaphezu kwalokho, ngenxa yokuthi i-Bacopa monnieri ilawula i-dopamine ne-serotonin, inganciphisa izinguquko ezibangelwa ukucindezeleka ku-dopamine ne-serotonin ku-hippocampus kanye ne-prefrontal cortex, iphinde igcizelele izimfanelo ze-adapogenic zalesi sitshalo.
Bacopa monnieriiphinde ikhulise ukukhiqizwa kwe-tryptophan hydroxylase (TPH2), i-enzyme ebalulekile ezinhlobonhlobo zemisebenzi yesistimu yezinzwa ephakathi, kuhlanganise ne-serotonin synthesis. Okubaluleke kakhulu, i-bacoside-A, esinye sezithako ezisebenzayo ku-Bacopa monnieri, ikhonjisiwe ukuthuthukisa umsebenzi we-GABA. I-GABA iyi-neurotransmitter ezolile, evimbelayo. I-Bacopa monnieri ingakwazi ukuqondisa umsebenzi we-GABA futhi yehlise umsebenzi we-glutamate, engasiza ekunciphiseni imizwa yokukhathazeka ngokunciphisa ukusebenza kwama-neurons angase avuswe ngokweqile. -muhle” vibe.
Isikhathi sokuthumela: Oct-08-2024
