• YiniI-PQQ ?
I-PQQ, igama eliphelele yi-pyrroloquinoline quinone. Njenge-coenzyme Q10, i-PQQ nayo iyi-coenzyme ye-reductase. Emkhakheni wezithako zokudla, ngokuvamile kubonakala njengomthamo owodwa (ngesimo sikasawoti we-disodium) noma ngesimo somkhiqizo ohlanganiswe ne-Q10.
Ukukhiqizwa kwemvelo kwe-PQQ kuphansi kakhulu. Itholakala enhlabathini nasezilwanyaneni ezincane, izitshalo nezicubu zezilwane, njengetiye, i-natto, i-kiwifruit, kanye ne-PQQ nayo ikhona ezicutshini zomuntu.
I-PQQinemisebenzi eminingi yomzimba. Ingakhuthaza i-mitochondria entsha kumaseli (i-mitochondria ibizwa ngokuthi "izitshalo zokucubungula amandla amaseli"), ukuze isivinini sokuhlanganisa amandla eseli singakhuphuka kakhulu. Ngaphezu kwalokho, i-PQQ iqinisekisiwe ezifundweni zezilwane nezabantu ukuthuthukisa ukulala, ukwehlisa amazinga e-cholesterol, ukunciphisa ingcindezi ye-oxidative, ukwelula impilo, ukukhuthaza ukusebenza kobuchopho futhi kudambise ukuvuvukala.
Ngo-2017, ithimba labacwaningi elakhiwe nguSolwazi Hiroyuki Sasakura nabanye baseNyuvesi yaseNagoya eJapane bashicilela imiphumela yabo yocwaningo encwadini ethi "JOURNAL OF CELL SCIENCE". I-coenzyme pyrroloquinoline quinone (PQQ) ingandisa impilo yama-nematode.
• Ziyini Izinzuzo ZezempiloI-PQQ ?
I-PQQ Ithuthukisa i-Mitochondria
Ocwaningweni lwezilwane, abacwaningi eNyuvesi yaseCalifornia bathola ukuthi i-PQQ ingakhuthaza ukukhiqizwa kwe-mitochondria enempilo. Kulolu cwaningo, ngemuva kokuthatha i-PQQ amasonto ayi-8, inani le-mitochondria emzimbeni liphindeke kabili. Kolunye ucwaningo lwezilwane, imiphumela ikhombise ukuthi ukungatheleleki kwehle kakhulu futhi nenani le-mitochondria lehliswa ngaphandle kokuthatha i-PQQ. Lapho i-PQQ iphinda yengezwa, lezi zimpawu zabuyiselwa ngokushesha.
Dambisa ukuvuvukala futhi uvimbele i-arthritisI-Antioxidant & nokuvikelwa kwemizwa
Asebekhulile bavame ukuhlushwa isifo samathambo, okuyisici esibalulekile esiholela ekukhubazekeni. Ucwaningo luye lwabonisa ukuthi izinga lokufa okuphelele kweziguli ezine-rheumatoid arthritis liphakeme ngama-40% kunelomphakathi jikelele. Ngakho-ke, umphakathi wesayensi ubulokhu ufuna ngenkuthalo izindlela zokuvimbela nokukhulula isifo samathambo. Ucwaningo olusanda kushicilelwa ephephabhukwini elithi Inflammation likhombisa lokhoI-PQQkungase kube umsindisi wesifo samathambo abacwaningi abebemfuna.
Esivivinyweni somtholampilo womuntu, ososayensi balingisa ukuvuvukala kwe-chondrocyte eshubhuni yokuhlola, bajova i-PQQ eqenjini elilodwa lamaseli, futhi abazange bajove elinye iqembu. Imiphumela yabonisa ukuthi izinga lama-enzyme ehlisa i-collagen (i-matrix metalloproteinases) eqenjini lama-chondrocyte angazange ajovwe nge-PQQ lenyuke kakhulu.
Ngezifundo ze-in vitro kanye ne-vivo, ososayensi bathole ukuthi i-PQQ ingavimbela ukukhishwa kwezinto ezivuvukalayo ngamaseli e-fibrotic synovial emalungeni, kuyilapho ivimbela ukusebenza kwezici zokuloba zenuzi ezibangela ukuvuvukala. Ngaso leso sikhathi, ososayensi bathole nokuthi i-PQQ inganciphisa ukusebenza kwama-enzyme athile (njenge-matrix metalloproteinases), aphula uhlobo lwe-2 lwe-collagen emalungeni futhi alimaze amalunga.
Ukuvikelwa kwe-Antioxidant nezinzwa
Ucwaningo luthole lokhoI-PQQinomphumela we-neuroprotective ku-rat midbrain neuronal umonakalo kanye nesifo sika-Parkinson esibangelwa i-rotenone.
Ukungasebenzi kahle kwe-Mitochondrial kanye nengcindezi ye-oxidative kukhonjiswe njengezimbangela ezimbili eziyinhloko zesifo sikaParkinson (PD). Ucwaningo lukhombisile ukuthi i-PQQ inomphumela onamandla wokulwa ne-antioxidant futhi ingavikela ku-cerebral ischemia ngokumelana nengcindezi ye-oxidative. Impendulo yengcindezi ye-oxidative ithathwa njengenye yezindlela ezibaluleke kakhulu eziholela ku-apoptosis yeseli. I-PQQ ingavikela amaseli e-SH-SY5Y ku-rotenone (i-neurotoxic agent) -induced cytotoxicity. Ososayensi basebenzisa i-PQQ pretreatment ukuvimbela i-apoptosis yeseli eyenziwe yi-rotenone, ukubuyisela amandla olwelwesi lwe-mitochondrial, futhi kuvimbele ukukhiqizwa kwezinhlobo ze-oxygen esebenzayo ye-intracellular (ROS).
Ngokuvamile, ucwaningo olunzulu ngendima yeI-PQQempilweni engokomzimba kungasiza abantu ukuthi bagweme ukuguga.
• Impahla EntshaI-PQQImpushana/Amaphilisi/Amaphilisi/Ama-Gummies
Isikhathi sokuthumela: Oct-26-2024
