Yini?I-Resveratrol?
I-resveratrol iyinhlanganisela yemvelo etholakala ezitshalweni ezithile, izithelo, newayini elibomvu. Kungokweqembu lezinhlanganisela ezibizwa nge-polyphenols, ezisebenza njengama-antioxidants futhi aziwa ngezinzuzo zawo zezempilo ezingaba khona. I-resveratrol igcwele kakhulu esikhumbeni samagilebhisi abomvu futhi kube yisihloko sezifundo eziningi ngenxa yemiphumela engaba khona ezicini ezihlukahlukene zempilo.
Olunye ucwaningo lubonisa ukuthi i-resveratrol ingaba nezinzuzo ezingaba khona empilweni yenhliziyo, njengoba ingasiza ukusekela imithambo yegazi enempilo nokujikeleza kwegazi. Ukwengeza, iye yafundelwa izakhiwo zayo ezingaba khona zokulwa nokuvuvukala kanye ne-antioxidant, ezingaba nomthelela ezinqubweni zezempilo kanye nokuguga jikelele.
I-Resveratrol nayo iphenywe ngendima yayo engaba khona ekusekeleni impilo yobuchopho nokusebenza kwengqondo, kanye nemiphumela yayo kumetabolism kanye nezinzuzo ezingaba khona zokulawulwa kwesisindo.
Izakhiwo Zomzimba Nezamakhemikhali ze-Resveratrol
I-Resveratrol (3-4'-5-trihydroxystilbene) iyinhlanganisela engeyona i-flavonoid polyphenol. Igama layo lamakhemikhali yi-3,4',5-trihydroxy-1,2-diphenylethylene (3,4',5-trihydroxystilbene), ifomula yayo yamangqamuzana i-C14H12O3, futhi isisindo sayo samangqamuzana yi-228.25.
I-resveratrol ehlanzekile ibonakala iyimpushana emhlophe kuya kokuphuzi ekhanyayo, engenaphunga, engancibiliki emanzini, futhi incibilika kalula kuzincibilikisi zemvelo ezifana ne-ether, i-chloroform, i-methanol, i-ethanol, i-acetone, ne-ethyl acetate. Iphuzu elincibilikayo lingu-253-255°C, kanti izinga lokushisa le-sublimation lingu-261°C. Ingaphenduka ibebomvu ngezisombululo ze-alkaline ezifana namanzi e-ammonia, futhi ingasabela nge-ferric chloride-potassium ferrocyanide. Lesi sakhiwo singasetshenziswa ukukhomba i-resveratrol.
I-resveratrol yemvelo inezakhiwo ezimbili, i-cis ne-trans. Itholakala ikakhulukazi ekuguqulweni kwemvelo. Lezi zakhiwo ezimbili zingahlanganiswa ne-glucose ukwakha i-cis ne-trans resveratrol glycosides. I-Cis- ne-trans-resveratrol glycosides ingakhulula i-resveratrol ngaphansi kwesenzo se-glycosidase emathunjini. Ngaphansi kokukhanya kwe-ultraviolet, i-trans-resveratrol ingaguqulwa ibe ama-cis-isomers.
Indlela Yokulungiselela
Indlela yokukhipha izitshalo zemvelo
Amagilebhisi, ama-knotweed namantongomane asetshenziswa njengezinto ezingavuthiwe ukuze kukhishwe futhi kuhlukaniswe i-resveratrol engahluziwe, bese iyayihlanza. Ubuchwepheshe obuyinhloko bokukhipha okungahluziwe buhlanganisa ukukhishwa kwe-organic solvent, ukukhishwa kwe-alkaline nokukhipha ama-enzyme. Izindlela ezintsha ezifana ne-microwave-assisted extraction, i-CO2 supercritical extraction kanye ne-ultrasonic-assisted extraction nazo ziyasetshenziswa. Injongo yokuhlanza iwukuhlukanisa i-cis- kanye ne-trans-isomers ye-resveratrol ne-resveratrol ku-resveratrol engahluziwe ukuze kutholwe i-trans-resveratrol. Izindlela zokuhlanza ezivamile zifaka i-chromatography, ikholomu ye-silica gel chromatography, i-chromatography yongqimba oluncane, ukusebenza okuphezulu kwe-chromatography ye-liquid, njll.
Indlela yokuhlanganisa
Kusukela okuqukethwei-resveratrolezitshalweni ziphansi kakhulu futhi izindleko zokukhipha ziphezulu, ukusetshenziswa kwamakhemikhali, i-biological, ubunjiniyela bezakhi zofuzo nezinye izindlela zokuthola i-resveratrol sekuyindlela ebaluleke kakhulu ekuthuthukisweni kwayo. Ukusabela kwe-Perkin, ukusabela kwe-Hech, kanye nokusabela kwe-Witting-Hormer izindlela zamakhemikhali ezivuthiwe zokukhiqiza i-resveratrol, enesivuno esingu-55.2%, 70%, kanye no-35.7% ngokulandelanayo. Ubuchwepheshe bobunjiniyela bezofuzo busetshenziselwa ukulawula noma ukuthuthukisa indlela ye-biosynthesis ye-resveratrol ukuze kutholwe izinhlobo zezitshalo ezikhiqiza kakhulu; izindlela ezifana nokusebenzisa i-mutagenesis ukuze ukhethe imigqa yeseli enesivuno esiphezulu ingakhuphula isivuno se-resveratrol ngezikhathi ezingu-1.5 ~ 3.0.
Iyini Inzuzo YaI-Resveratrol?
I-Resveratrol ibe yisihloko socwaningo ngenxa yezinzuzo zayo zezempilo ezingaba khona. Ezinye zezinzuzo ezingaba khona ze-resveratrol zifaka:
1.Ukunqanda ukuguga
Ngo-2003, uprofesa waseHarvard University uDavid Sinclair kanye nethimba lakhe bathola ukuthi i-resveratrol ingenza kusebenze i-acetylase futhi yandise isikhathi sokuphila se-yeast, okubangele ukwanda kocwaningo lokulwa nokuguga lwe-resveratrol. Howitz et al. ithole ukuthi i-resveratrol ingasebenza njengesisebenzeli esiqine kakhulu somthethonqubo wolwazi othulile we-2 homolog1 (SIRT1), ingalingisa impendulo elwa nokuguga ye-calorie restriction (CR), futhi ibambe iqhaza ekulawuleni isilinganiso seminyaka yokuphila kwezinto eziphilayo. . I-CR ingumdubuli oqinile we-SIRT1 futhi ingakhuphula ukubonakaliswa kwe-SIRT1 ezithweni nasezicutshini ezinjengobuchopho, inhliziyo, amathumbu, izinso, imisipha namafutha. I-CR ingabangela izinguquko zomzimba ezibambezela ukuguga futhi zandise isikhathi sokuphila, okubaluleke kakhulu okunganwetshwa ngo-50%. . Ucwaningo luye lwaqinisekisa ukuthi i-resveratrol inganweba isikhathi sokuphila kweyeast, nematodes, fruit fly kanye nezinhlanzi eziphansi.
2.Anti-isimila, anti-umdlavuza
I-Resveratrol inemiphumela ebalulekile yokuvimbela kumaseli ahlukahlukene wesimila njengegundane i-hepatocellular carcinoma, umdlavuza webele, umdlavuza wekoloni, umdlavuza wesisu, kanye ne-leukemia. Ezinye izazi ziye zaqinisekisa ukuthi i-resveratrol inomphumela obalulekile wokuvimbela kumaseli e-melanoma ngokusebenzisa indlela ye-MTT kanye ne-cytometry yokugeleza.
Kunemibiko yokuthi i-resveratrol ingathuthukisa i-radiotherapy yomdlavuza futhi ivimbele ngempumelelo imiphumela yamangqamuzana omdlavuza. Kodwa kuze kube manje, ngenxa yobunzima be-resveratrol's anti-tumor mechanism, abacwaningi abakafinyeleli ukuvumelana ngendlela yayo yokusebenza.
3.Vimbela futhi welaphe isifo senhliziyo nemithambo yegazi
Ucwaningo lwe-Epidemiological luye lwathola ukuthi into ethi "i-French Paradox" ukuthi abantu baseFrance badla inani elikhulu lamafutha nsuku zonke, kodwa izigameko nokufa kwezifo zenhliziyo ziphansi kakhulu kunamanye amazwe aseYurophu. Lesi simo singase sihlobane nokusetshenziswa kwabo kwansuku zonke kwenani elikhulu lewayini. , futhi i-resveratrol ingaba isici sayo esiyinhloko esiyisivikelo. Ucwaningo lubonisa ukuthi i-resveratrol ingalawula amazinga e-cholesterol yegazi ngokubopha kuma-estrogen receptors emzimbeni womuntu, ivimbele amaplatelet ukuthi enze amahlule egazi futhi anamathele ezindongeni zemithambo yegazi, ngaleyo ndlela ivimbele futhi yehlise ukwenzeka kanye nokukhula kwesifo senhliziyo, futhi yehlise ubungozi bokuvela kwezifo zenhliziyo. isifo senhliziyo emzimbeni womuntu. Ingozi yesifo se-vascular.
4.Ukwesekwa Kwe-Antioxidant:I-Resveratrolisebenza njenge-antioxidant, isiza ukuvikela amaseli emonakalweni we-oxidative obangelwa ama-radicals mahhala. Lokhu kungase kube nomthelela kuyo yonke impilo kanye nezinqubo zokuguga.
6. Impilo Yobuchopho: Ucwaningo luhlole indima engaba khona ye-resveratrol ekusekeleni impilo yobuchopho nokusebenza kwengqondo, ngocwaningo oluthile oluphakamisa izici ze-neuroprotective.
I-7.I-Metabolism kanye Nokulawulwa Kwesisindo: I-Resveratrol iphenywe ngemiphumela yayo engase ibe khona ku-metabolism kanye nendima yayo ekusekeleni ukuphathwa kwesisindo esinempilo.
Ziyini Izicelo ZeI-Resveratrol?
I-Resveratrol inezinhlelo zokusebenza ezihlukahlukene futhi isetshenziswa emikhakheni ehlukene ngenxa yezinzuzo zayo zezempilo ezingaba khona. Ezinye zezicelo ze-resveratrol zifaka:
1. Izithako Zokudla: I-Resveratrol ivame ukusetshenziswa ezithasiselweni zokudla, evame ukudayiswa ngenxa yezakhiwo zayo ezingase zibe ne-antioxidant kanye ne-anti-aging.
2. Imikhiqizo ye-Skincare: I-Resveratrol ifakiwe kweminye imikhiqizo ye-skincare ngenxa yezakhiwo zayo zokulwa ne-antioxidant, engasiza ukuvikela isikhumba ekulimaleni kwemvelo futhi isekele impilo yesikhumba iyonke.
3. Ukudla Okusebenzayo Neziphuzo: I-Resveratrol ngezinye izikhathi yengezwa ekudleni okusebenzayo neziphuzo, njengeziphuzo zamandla kanye nemikhiqizo yokudla egxile empilweni, ukunikeza izinzuzo zezempilo ezingase zibe khona.
4. Ucwaningo Nokuthuthukiswa: I-Resveratrol iyaqhubeka nokuba yisihloko socwaningo lwesayensi, ngezifundo eziqhubekayo ezihlola izinhlelo zayo ezingase zibe khona ezimweni ezihlukahlukene zezempilo kanye nemiphumela yayo ekugugeni, imetabolism, kanye nokuphila kahle.
Iyini I-Downside Of Resveratrol?
Nakuba i-resveratrol ifundelwe ngezinzuzo zayo zezempilo ezingaba khona, kubalulekile ukucabangela ukwehla okungaba khona noma imikhawulo ehambisana nokusetshenziswa kwayo. Ezinye izinto ezicatshangelwayo mayelana nokwehla kwe-resveratrol zifaka:
1. I-Bioavailability Elinganiselwe: I-Resveratrol inokutholakala okuphansi kwe-bioavailability, okusho ukuthi umzimba ungase ungayimunce futhi uyisebenzise ngokuphumelelayo lapho ithathwa ngomlomo. Lokhu kungathinta ukusebenza kahle kwayo ekukhiqizeni imiphumela yezempilo oyifunayo.
2. Ukushoda kokulinganisa: Ikhwalithi kanye nokugxila kwezithako ze-resveratrol kungahluka, futhi kukhona ukuntuleka kokumisa ekukhiqizeni lezi zithako. Lokhu kungenza kube inselele kubathengi ukunquma umthamo ofanelekile kanye nekhwalithi yomkhiqizo.
3. Ukusebenzisana Okungenzeka: I-Resveratrol ingase ihlanganyele nemithi ethile noma izimo zempilo. Kubalulekile ukubonisana nochwepheshe bezempilo ngaphambi kokusebenzisa i-resveratrol, ikakhulukazi uma uthatha eminye imithi noma unezinto ezithile ezikukhathazayo ngezempilo.
4. Imikhawulo yocwaningo: Nakuba ezinye izifundo zibonise imiphumela ethembisayo, ucwaningo olwengeziwe luyadingeka ukuze kuqondwe ngokugcwele imiphumela yesikhathi eside, umthamo ophelele, kanye nezingozi ezingaba khona ezihlobene ne-resveratrol supplementation.
Njenganoma yisiphi isithasiselo, kuyatuseka ukuthi usondele ekusetshenzisweni kwe-resveratrol ngokucophelela futhi ngaphansi kokuqondisa kochwepheshe bezempilo, ikakhulukazi uma unezinto ezithile ezikukhathazayo ngezempilo noma uthatha eminye imithi.
Imibuzo Ehlobene Ongase Ube Nentshisekelo Kuyo:
Ubani okufanele agwemei-resveratrol?
Abantu abathile kufanele baqaphele noma bagweme i-resveratrol, ikakhulukazi efomini lesengezo eligxilisiwe. Kuyatuseka ukuthi amaqembu alandelayo axhumane nochwepheshe bezempilo ngaphambi kokusebenzisa i-resveratrol:
1. Abesifazane Abakhulelwe noma Abancelisa Ibele: Ngenxa yocwaningo olulinganiselwe emiphumeleni ye-resveratrol phakathi nokukhulelwa nokuncelisa, kunconywa kwabesifazane abakhulelwe noma abancelisa ibele ukuthi bafune isiqondiso kuchwepheshe wezempilo ngaphambi kokusebenzisa izithasiselo ze-resveratrol.
2. Abantu Abathatha Izidakamizwa Zegazi: I-Resveratrol ingase ibe nezakhiwo ezithambile ze-anticoagulant, ngakho-ke abantu abathatha imithi enciphisa igazi kufanele babonane nochwepheshe bezempilo ngaphambi kokusebenzisa i-resveratrol ukuze bagweme ukusebenzisana okungenzeka.
3. Labo Abanezimo Ezizwelayo I-Hormone: I-Resveratrol iye yafundelwa imiphumela yayo engaba khona ekulawuleni ama-hormone, ngakho-ke abantu abanezimo ezizwela ama-hormone noma labo abathola ukwelashwa kwama-hormone kufanele basebenzise i-resveratrol ngokuqapha nangaphansi kokuqondisa kwezokwelapha.
4. Abantu AbaneZimo Zesibindi: Ezinye izifundo ziye zaphakamisa ukuthi imithamo ephezulu ye-resveratrol ingase ibe nemiphumela esibindini. Abantu abanezimo zesibindi noma labo abaphuza imithi ethinta isibindi kufanele basebenzise i-resveratrol ngokuqapha nangaphansi kokuqondisa kodokotela.
Njenganoma yisiphi isithasiselo, kubalulekile ukubonisana nochwepheshe bezempilo ngaphambi kokusebenzisa i-resveratrol, ikakhulukazi uma unokukhathazeka okuthile ngezempilo, uphuza imithi, noma unezimo zempilo ezicashile.
I-resveratrol yenzani esikhumbeni?
I-Resveratrol kukholakala ukuthi inikeza izinzuzo eziningi ezingaba khona esikhumbeni, okuholele ekufakweni kwayo emikhiqizweni ye-skincare. Eminye yemiphumela ye-resveratrol esikhumbeni ingabandakanya:
1. Ukuvikelwa Kwe-Antioxidant: I-Resveratrol isebenza njenge-antioxidant, isiza ukunciphisa ama-radicals mahhala futhi inciphise ukucindezeleka okwenziwe nge-oxidative esikhumbeni. Lokhu kungase kuvikele isikhumba ekulimaleni kwemvelo, njengemisebe ye-UV kanye nokungcola.
2. Izakhiwo Zokuguga: I-Resveratrol kucatshangwa ukuthi inemiphumela yokuguga, njengoba ingasiza ekunciphiseni ukubukeka kwemigqa emihle nemibimbi, ithuthukise ukunwebeka kwesikhumba, futhi isekele impilo yonke yesikhumba.
3. I-Anti-Inflammatory Effects: I-Resveratrol iye yafundelwa izici zayo ezingaba zokuqeda ukuvuvukala, ezingasiza ukuthobisa nokuthulisa isikhumba, ikakhulukazi kubantu abanesikhumba esibucayi noma esisebenzayo.
4. Ukukhanya Kwesikhumba: Olunye ucwaningo lubonisa ukuthi i-resveratrol ingase ibe nomthelela ekukhanyeni kwesikhumba kanye nethoni yesikhumba yakusihlwa, okungase kunciphise ukubukeka kwe-hyperpigmentation.
Yikuphi ukudla okuphezulu ku-resveratrol?
Ukudla okuphezulu kakhulu ku-resveratrol kufaka:
1. Amagilebhisi Abomvu: I-Resveratrol igcwele kakhulu esikhumbeni samagilebhisi abomvu, okwenza iwayini elibomvu libe umthombo we-resveratrol. Kodwa-ke, kubalulekile ukuphuza utshwala ngokusesilinganisweni, futhi eminye imithombo ye-resveratrol ingase ikhethelwe abangaphuzi.
2. Amantongomane: Izinhlobo ezithile zamantongomane, ikakhulukazi isikhumba samantongomane, aqukethe inani eliphawulekayo le-resveratrol.
3. Amajikijolo aluhlaza okwesibhakabhaka aziwa ngokuqukethwe kwawo kwe-antioxidant, futhi aqukethe i-resveratrol, nakuba ngamanani amancane uma kuqhathaniswa namagilebhisi abomvu namakinati.
4. Ama-Cranberries: Ama-Cranberries angomunye umthombo we-resveratrol, ehlinzeka ngenani elilinganiselwe lale nhlanganisela.
5. Ushokoledi Omnyama: Ezinye izinhlobo zikashokoledi omnyama ziqukethe i-resveratrol, enikeza indlela emnandi yokuhlanganisa le nhlanganisela ekudleni.
Ingabe kulungile ukuthatha i-resveratrol nsuku zonke?
Isinqumo sokuthatha i-resveratrol nsuku zonke kufanele senziwe ngokubonisana nochwepheshe bezempilo, ikakhulukazi uma kucatshangelwa ukwesekwa kwe-resveratrol. Nakuba i-resveratrol ngokuvamile ibhekwa njengephephile uma idliwe ngamanani avame ukutholakala ekudleni, ukuphepha kanye nezinzuzo ezingaba khona ze-resveratrol supplementation yansuku zonke zingahluka ngokusekelwe esimweni sezempilo ngasinye, izimo zezokwelapha ezikhona, kanye neminye imithi ethathwayo.
Ingabe i-resveratrol inobuthi esibindini?
I-Resveratrol iye yafundelwa imiphumela yayo engaba khona esibindini, kanti nakuba ngokuvamile ibhekwa njengephephile uma idliwe ngamanani avame ukutholakala ekudleni, kunobunye ubufakazi obubonisa ukuthi imithamo ephezulu ye-resveratrol ingase ibe nemiphumela esibindini. Ezinye izifundo zibonise ukuthi imithamo ephezulu ye-resveratrol ingase iholele ebusheni besibindi ezimweni ezithile.
Kubalulekile ukuqaphela ukuthi ucwaningo ngalesi sihloko lusaqhubeka, futhi amandla okuba nobuthi besibindi angase athonywe izici ezifana nesilinganiso, ubude besikhathi sokusetshenziswa, kanye nezimo zempilo ngazinye. Njenganoma yisiphi isithasiselo, kuyatuseka ukuthintana nochwepheshe bezokunakekelwa kwempilo ngaphambi kokusebenzisa i-resveratrol, ikakhulukazi uma unezinto ezithile ezikukhathazayo ngezempilo noma uthatha eminye imithi engase iphazamise ukusebenza kwesibindi.
Ingabe i-resveratrol ayilungile ezinso?
Kunobufakazi obulinganiselwe bokuphakamisa ukuthi i-resveratrol ayilungile ezinso. Kodwa-ke, njenganoma yisiphi isithasiselo, kubalulekile ukusondela ekusetshenzisweni kwaso ngokuqapha, ikakhulukazi uma unezimo ezikhona zezinso noma uthatha imithi engase iphazamise ukusebenza kwezinso. Kutuswa ukuthi uthintane nochwepheshe bezokunakekelwa kwempilo ukuze uthole ukuthi i-resveratrol supplementation ifanele yini izidingo zakho zezempilo, ikakhulukazi uma unokukhathazeka ngomthelela wayo ongaba khona empilweni yezinso.
Okungaxutshwa nakhoi-resveratrol?
Uma ucabangela ukwesekwa kwe-resveratrol, kubalulekile ukuqaphela ukusebenzisana okungaba khona nezinye izinto. Okunye okucatshangelwayo kokungaxutshwa ne-resveratrol kufaka phakathi:
1. Imithi Yokunciphisa Igazi: I-Resveratrol ingase ibe nezakhi ezinciphisa ukopha, ngakho-ke kubalulekile ukuqaphela lapho uthatha i-resveratrol eceleni kwemithi yokunciphisa igazi, njengoba ingase yandise ingozi yokopha.
2. Ezinye Izithako Ze-Antioxidant: Nakuba ama-antioxidants ngokuvamile enenzuzo, ukuthatha imithamo ephezulu yezithako eziningi ze-antioxidant ngesikhathi esisodwa kungase kube nemiphumela engahlosiwe. Kutuswa ukuthi uthintane nochwepheshe bezempilo ngaphambi kokuhlanganisa i-resveratrol nezinye izithasiselo ze-antioxidant.
3. Imithi Ethile: I-Resveratrol ingase ihlanganyele nemithi ethile, kuhlanganise naleyo ehlanganiswe yisibindi. Kubalulekile ukuxoxa ngokusebenzelana okungase kube khona nochwepheshe bezempilo, ikakhulukazi uma uthatha eminye imithi.
Njenganoma yisiphi isithasiselo, kubalulekile ukufuna isiqondiso kuchwepheshe wezokunakekelwa kwempilo ukuze unqume ukusetshenziswa okufanele kakhulu kwe-resveratrol ngokusekelwe esimweni sezempilo ngasinye kanye nokusebenzisana okungaba khona nezinye izinto.
Ngingakwazi ukusebenzisa uvithamini C nge-resveratrol?
Yebo, ungasebenzisa uvithamini C ngokujwayelekile nge-resveratrol. Eqinisweni, olunye ucwaningo lubonisa ukuthi ukuhlanganisa i-resveratrol ne-vitamin C kungase kuthuthukise imiphumela ye-antioxidant yazo zombili izinhlanganisela. I-Vitamin C iyi-antioxidant eyaziwayo engagcwalisa izinzuzo ezingaba khona ze-resveratrol. Kodwa-ke, njenganoma iyiphi inhlanganisela yezithasiselo, kuyatuseka ukuthintana nochwepheshe bezokunakekelwa kwempilo ukuze uqinisekise ukuthi le nhlanganisela ifanele izidingo zakho zezempilo kanye nokuxoxa nganoma yikuphi ukusebenzelana okungaba khona noma ukucatshangelwa.
Isikhathi sokuthumela: Sep-09-2024
