Ekutholakaleni okudabukisayo, ososayensi bathole lokhoI-D-ribose, ingqamuzana likashukela elilula, linendima ebalulekile ekukhiqizeni amandla ngaphakathi kwamangqamuzana. Lokhu okutholakele kunomthelela omkhulu ekuqondeni i-metabolism yamaselula futhi kungaholela ekwelashweni okusha kwezinhlobonhlobo zezifo, okubandakanya izimo zenhliziyo nokuphazamiseka kwemisipha.
Isayensi EsemuvaI-D-Ribose: Ukwembula Iqiniso:
I-D-riboseiyingxenye eyinhloko ye-adenosine triphosphate (ATP), i-molecule esebenza njengohlobo lwemali lwamandla oluyinhloko kumaseli. Abacwaningi kudala bazi ukuthi i-ATP ibalulekile ekunikezeni amandla izinqubo zamaselula, kodwa indima ethileI-D-riboseekukhiqizweni kwe-ATP bekulokhu kunzima kuze kube manje. Ukutholwa kunikeza ukukhanya ezindleleni eziyinkimbinkimbi ze-biochemical ezisekela ukukhiqizwa kwamandla amaselula.
Imithelela yalokhu kutholwa mikhulu. Ngokuqonda indima yeI-D-riboseekukhiqizweni kwe-ATP, ososayensi bangakwazi ukuthuthukisa izindlela zokwelapha ezihlosiwe ezimweni ezibonakala ngokuphazamiseka kwemetabolism yamandla. Lokhu kungaba nomthelela omkhulu ezigulini ezinesifo senhliziyo, i-muscular dystrophy, nezinye iziyaluyalu ezibandakanya ukukhiqizwa kwamandla kwamaselula.
Ngaphezu kwalokho, ukutholakala kweI-D-riboseIqhaza lamaselula ekukhiqizweni kwamandla eselula livula izindlela ezintsha zokucwaninga ngezinkinga ze-metabolic. Ngokuthola ukuqonda okujulile kokuthi kanjaniI-D-riboseinikela ekuhlanganiseni kwe-ATP, ososayensi bangakwazi ukuhlonza okuhlosiwe okusha kokuthuthukiswa kwezidakamizwa, okungase kuholele ekwelashweni okuphumelelayo kohlu lwezimo ze-metabolic.
Sekukonke, ukutholakala kweI-D-riboseIndima yamaselula ekukhiqizweni kwamandla eselula imele intuthuko enkulu ekuqondeni kwethu umzimba weselula. Lokhu okutholakele kunamandla okuguqula ukwelashwa kwezifo ezihlobene nokukhiqizwa kwamandla futhi kungavula indlela yokuthuthukiswa kwezindlela zokwelapha ezintsha eziqondise izinqubo eziyisisekelo ze-metabolic. Njengoba ososayensi beqhubeka nokuveza ubunkimbinkimbi bokukhiqizwa kwamandla eselula, amathuba empumelelo emisha ekwelashweni kwezokwelapha aya ngokuya ethembisa.
Isikhathi sokuthumela: Aug-08-2024
