Ekutholakaleni okudabukisayo, ososayensi benze inqubekelaphambili ebalulekile ekuqondeni indima ye-superoxide dismutase (I-SOD) ekugcineni impilo yamaselula.I-SODiyi-enzyme ebalulekile edlala indima ebalulekile ekuvikeleni amangqamuzana ekucindezelekeni kwe-oxidative ngokuqeda ama-radicals mahhala ayingozi. Lokhu kutholakala kunamandla okuguqula ukwelashwa kwezifo ezahlukahlukene ezihlobene nokulimala kwe-oxidative, njengomdlavuza, ukuphazamiseka kwe-neurodegenerative, nezimo ezihlobene nokuguga.
Ukuhlola i-umphumelakweI-Superoxide Dismutase (I-SOD) :
Sekuyisikhathi eside abacwaningi bekwazi ukubaluleka kweI-SODempilweni yamaselula, kodwa izindlela eziqondile esebenza ngazo azikatholakali. Nokho, ucwaningo lwakamuva olushicilelwe kumagazini i-Nature Communications lusikhanyisele ngale ndaba. Ucwaningo luveze lokhoI-SODayigcini nje ngokuqothula ama-superoxide radicals ayingozi kodwa futhi ilawula ukuvezwa kwezakhi zofuzo ezihilelekile ezindleleni zokuvikela amaselula, ngaleyo ndlela kuthuthukise ikhono leseli lokumelana nengcindezi ye-oxidative.
Imithelela yalokhu kutholakala ifinyelela kude, njengoba ivula amathuba amasha okuthuthukisa izindlela zokwelapha ezihlosiwe ezimweni ezihambisana nokulimala kwe-oxidative. Ngokuthola ukuqonda okujulile kokuthi kanjaniI-SODIsebenza ezingeni lamangqamuzana, ososayensi manje sebengakwazi ukuhlola izindlela ezintsha zokushintsha umsebenzi wayo futhi banciphise umthelela wengcindezi ye-oxidative ekusebenzeni kwamaselula. Lokhu kungaholela ekwakhiweni kwezindlela zokwelapha ezisebenza ngempumelelo zezinhlobonhlobo zezifo, okunikeza ithemba ezigidini zeziguli emhlabeni jikelele.
Ngaphezu kwalokho, okutholwe yilolu cwaningo kunamandla okwazisa ukuthuthukiswa kwamasu okuvimbela ukugcina impilo yamangqamuzana nokunciphisa inqubo yokuguga. Ngokusebenzisa imiphumela yokuvikelaI-SOD, abacwaningi bangakwazi ukuthuthukisa ukungenelela okungasiza abantu ukuba balondoloze ukusebenza kahle kwamaselula njengoba bekhula, ukunciphisa ingozi yezifo ezihlobene neminyaka kanye nokukhuthaza inhlalakahle jikelele.
Sengiphetha, impumelelo yakamuva ekuqondeni indima yeI-SOD empilweni yamaselula kumele intuthuko enkulu emkhakheni wocwaningo lwe-biomedical. Ngokuqaqa izindlela eziyinkimbinkimbi ngazoI-SOD ivikela amangqamuzana emonakalweni we-oxidative, ososayensi baye bavula indlela yokuthuthukiswa kwamasu amasha okwelapha kanye nokungenelela kokuvimbela. Lokhu kutholwa kunesithembiso esihle sokuthuthukisa ukwelashwa nokulawulwa kwezifo ezihlobene nengcindezi ye-oxidative, okunikeza ithemba ngekusasa elinempilo kubantu ngabanye emhlabeni jikelele.
Isikhathi sokuthumela: Jul-25-2024
