Entuthukweni edabukisayo, ososayensi benze igxathu elibalulekile ekuqondeni indima yeNAD+(nicotinamide adenine dinucleotide) ekusebenzeni kwamaselula kanye nomthelela wayo ongaba khona empilweni nasekuphileni isikhathi eside. I-NAD+ iyi-molecule ebaluleke kakhulu ebandakanyeka ezinqubweni ezihlukahlukene zebhayoloji, okuhlanganisa amandla e-metabolism, ukulungiswa kwe-DNA, nokuvezwa kofuzo. Lolu cwaningo lwakamuva lusikhanyisela ngokubaluleka kwe-NAD+ ekugcineni impilo yamaselula namandla ayo njengento okuhloswe ngayo ukungenelela kwezokwelapha.
Ukwembula Amandla weNAD+:
I-NAD+ idlala indima ebalulekile ekusebenzeni kwamaselula ngokusebenza njenge-coenzyme yama-enzyme amaningana abalulekile abandakanyeka ekukhiqizweni kwamandla nasekulungiseni i-DNA. Njengoba sikhula, amazinga e-NAD+ ayehla, okuholela ekwehleni kokusebenza kwamaselula kanye nokuba sengozini eyengeziwe yezifo ezihlobene nobudala. Okutholakele okusha kugqamisa amandla e-NAD+ njengomdlali oyinhloko ekukhuthazeni ukuguga okunempilo nokuphila isikhathi eside.
Ngaphezu kwalokho, ucwaningo luveze ukuthi amazinga e-NAD+ angathonywa yizinto ezahlukahlukene, okubandakanya ukudla, ukuvivinya umzimba, nokukhetha indlela yokuphila. Ngokuqonda izici ezithinta amazinga e-NAD+, abacwaningi banethemba lokuthuthukisa amasu okugcina amazinga e-NAD+ alungile nokukhuthaza impilo nokuphila kahle iyonke. Lolu cwaningo luvula amathuba amasha okungenelela komuntu siqu okuhloselwe ukulondoloza amazinga e-NAD+ nokukhuthaza ukuguga okunempilo.
Umphakathi wesayensi uya ngokuya uqaphela amandla weNAD+njengenhloso yokungenelela kwezokwelapha. Ngokuqonda izindlela zamangqamuzana ezisebenza ngaphansi kwe-NAD+, abacwaningi bangathuthukisa izindlela ezintsha zokushintsha amazinga e-NAD+ futhi banciphise ukwehla okuhlobene nobudala ekusebenzeni kwamaselula. Lokhu kungaholela ekwakhiweni kwezindlela zokwelapha ezintsha zezifo ezihlobene nobudala futhi kukhuthaze ukuguga okunempilo.
Imithelela yalolu cwaningo ibanzi, futhi ingasetshenziswa emikhakheni eyahlukene, okuhlanganisa ucwaningo lokuguga, imithi yokuvuselela, nokuvimbela izifo. Ukuqonda okusha okutholakele komsebenzi we-NAD+ kanye nomthelela wayo empilweni yamaselula kunamandla okuguqula indlela esibhekana ngayo nokuguga kanye nezifo ezihlobene nobudala. Ngocwaningo olwengeziwe nentuthuko, i-NAD+ ingavela njengomdlali obalulekile ekukhuthazeni ukuphila isikhathi eside nasekuthuthukiseni impilo nokuphila kahle iyonke.
Sengiphetha, impumelelo yakamuva kuNAD+ucwaningo luye lwasikhanyisela ngendima ebalulekile yale molekyuli ekusebenzeni kwamangqamuzana kanye nomthelela wayo ongaba khona empilweni nasekuphileni isikhathi eside. Ngokuqonda izici ezithonya amazinga e-NAD+ kanye nokuthuthukisa amasu okugcina amazinga afanele, abacwaningi bavula indlela yokungenelela okusha okuhloswe ngayo ukugqugquzela ukuguga okunempilo kanye nokunciphisa ukwehla okuhlobene neminyaka ekusebenzeni kwamaselula. Imithelela yalolu cwaningo ijulile, inamandla okuguqula indlela esibhekana ngayo nokuguga kanye nezifo ezihlobene nobudala.
Isikhathi sokuthumela: Aug-28-2024
