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Umsebenzi:

1. Ithuthukisa isifo sesisu

Kutholakale ukuthi umphumela we-polysaccharide ezifweni zesisu ubonakaliswe ngokuyinhloko kulezi zici ezintathu ezilandelayo: (1) I-polysaccharide yaba nomthelela wokukhipha i-Helicobacter pylori, ukuvimbela ukwanda kwe-Helicobacter pylori nokuvimbela ukubopha kwayo nge-gastric mucosa; (2) Inomphumela wokuvikela ulwelwesi lwesisu kanye nokwelapha isilonda esiswini, futhi inomphumela omuhle wokudambisa utshwala nokulimala okubangelwa izidakamizwa okubangelwa yizidakamizwa kanye nesilonda sesisu esingapheli; (3) I-Fucoidan inomphumela wokulwa nomdlavuza wesisu, ingavimbela ukwanda kwamangqamuzana omdlavuza wesisu, inciphise imiphumela emibi yokwelashwa ngamakhemikhali, futhi ithuthukise izinga lempilo yeziguli.

2. Umphumela we-Anticoagulant

I-Fucoidan inemisebenzi eminingi yezinto eziphilayo, kodwa umsebenzi wayo we-anticoagulant yiwo ocwaningwa kakhulu. Ucwaningo luye lwabonisa ukuthi ama-polysaccharides akhishwe ku-algae ehlukene yase-Marine ansundu anamazinga ahlukene omsebenzi we-anticoagulant. Isibonelo, ama-polysaccharides avela futhi abonisa izinga eliphezulu lomsebenzi we-anticoagulant, nomsebenzi we-anticoagulant futhi wawuyingxenye yalowo wangaphambili, kodwa cishe awukho umsebenzi we-anticoagulant.

3. Umphumela we-Antithrombotic

Kumodeli yokuhlola yezilwane eziphilayo, i-polysaccharide ye-fucoidan inomphumela ovimbelayo kukho kokubili i-venous thrombosis kanye ne-arterial thrombosis. Rocha et al. ithole ukuthi i-polysaccharide yayingenawo umsebenzi we-anticoagulant ku-vitro, kodwa ibonise umphumela osobala we-antithrombotic kumodeli yezilwane yokwakha i-venous thrombosis, futhi umphumela wawuncike esikhathini, ufinyelela ubuningi ngemva kwe-8h yokuphatha. Umsebenzi we-anticoagulant we-polysaccharide cishe wawuhlobene nokugqugquzela ukukhiqizwa kwe-heparin sulfate ngamaseli endothelial.

4. Umphumela we-Antiviral

Ucwaningo luye lwabonisa ukuthi ama-polysaccharides ane-sulfated (kuhlanganise ne-fucoidan polysaccharides) abonisa umsebenzi wokulwa namagciwane kokubili ku-vivo kanye ne-in vitro. UHayashi et al. wafunda umphumela wokuzivikela we-fucoidan ku-herpes simplex virus (HSV). Bathole ukuthi i-fucoidan ingavikela amagundane ekuthelelekeni nge-HSV, futhi yaveza ukuthi i-fucoidan ingase ivimbele ukutheleleka kwe-HSV ngokuvimbela ngokuqondile ukuphindaphinda kwegciwane kanye nokuthuthukisa umsebenzi wokuzivikela ozalwa naso futhi ozuziwe. Ngesikhathi esifanayo, kwatholakala nokuthi i-polysaccharide ibonise umsebenzi we-antiviral ngokumelene ne-HSV-1 ne-HSV-2. Hidari et al. ibike ukuthi i-fucoidan inganqanda ngempumelelo ukutheleleka kwegciwane lodenga 2 (DEN2), futhi yabonisa ukuthi i-fucoidan ibophezela ezinhlayiyeni ze-DEN2 futhi ihlanganyele ne-glycoprotein yayo yokupakisha. Ayinayo i-passivation effect eqondile kuma-virions, futhi indlela yayo ye-antiviral iwukuvimbela ukwakheka kwama-cytiocyte egciwane ngokuvimbela ukubhebhetheka kwegciwane.

5. Umphumela wokulwa nesimila

I-Fucoidan ithathwa njenge-ejenti yemvelo yokulwa nomdlavuza, futhi umsebenzi wayo wokulwa nesimila ubikwe ngokuqhubekayo. U-Alekseyenko et al. wafunda umsebenzi wokulwa nesimila we-fucoidan kumagundane aphethwe yi-Lewis lung adenocarcinoma, futhi waphakela i-fucoidan ngethamo elingu-10mg/kg kumagundane, okuholele ekusebenzeni okusesilinganisweni kokulwa nesimila kanye nomphumela wokulwa ne-tumor metastasis. Olunye ucwaningo luphinde lwathola ukuthi izinga lokuvimbela isimila se-fucoidan ezilwaneni ezi-5 eziqukethe i-S180 sarcoma lalingu-30%, kanye ne-sarcoma yezilwane ezi-2 zehla ngokuphelele. Esitsheni se-petri esinamaseli omdlavuza wekholoni angaba ngu-10,000 aphathwe ngama-polysaccharides emvelo e-algae atholakala ku-kelp, amaphesenti angama-50 amangqamuzana omdlavuza ashona ngemva kwamahora angu-24, futhi cishe wonke amangqamuzana omdlavuza afa ngemva kwamahora angu-72. Hyun et al. ithole ukuthi i-polysaccharide ye-algae ye-rock ingavimbela ngokuphawulekayo ukukhula kwamangqamuzana omdlavuza we-colon HCT-15. Ngemuva kokwelashwa kwe-HCT-15 cell line ne-rock algae polysaccharide, izenzakalo ze-apoptotic ezifana nokuphuka kwe-DNA, ukuhlanganisa i-chromosome, nokwanda kwamaseli e-subdiploid esigabeni se-G1 kwavela.

6. Imiphumela ye-Antioxidant

Inani elikhulu lokuhlolwa kwe-in vitro libonise ukuthi i-polysaccharide ye-rock algae inomsebenzi omkhulu we-antioxidant, iwuhlobo lwe-antioxidant yemvelo, futhi ingavimbela ngempumelelo isifo esibangelwa ama-radicals mahhala. Costa et al. ikhishwe i-polysaccharides e-sulfated ezinhlotsheni ze-11 zolwandle lwasolwandle olushisayo, konke okunomsebenzi we-antioxidant, ikhono lokwenza ama-chelates ane-ferrous namandla okunciphisa, i-5 yayo eyayinamandla okukhipha ama-hydroxyl radicals, futhi i-6 yayo inamandla okususa ama-peroxy radicals. UMicheline et al. kubika ukuthi ama-polysaccharides avela ku-algae angavimbela ukwakheka kwe-hydroxyl radical kanye ne-superoxide radical.

7. Umsebenzi wokuzivikela komzimba

I-Fucoidan inemisebenzi eminingi yokuzivikela komzimba, okuhlanganisa umsebenzi wokulwa nokuhambisana, impendulo ephikisana nokuvuvukala kanye nemiphumela ye-immunomodulatory. Tissot et al. kuqinisekisile ukuthi i-polysaccharide ye-fucoite ingavimbela amaprotheni ahambisanayo ku-serum yomuntu evamile, ngaleyo ndlela ivimbele ukuqedwa kwamangqamuzana egazi abomvu ezimvu okubangelwa ukusebenza komphelelisi, nokuvimbela ukusebenza komphelelisi ngokuvimbela isinyathelo sokuqala se-activation pathway yakudala (kuhlanganise ingxenye yokuqala yesiphelelisi, ingxenye yesibili kanye nengxenye yesine). Yang et al. ithole ukuthi i-fucoidan ingavimbela ngokukhetha ukubonakaliswa kwe-inducible nitric oxide synthase kumaseli avuthayo futhi inomsebenzi wokulwa nokuvuvukala. Mizuno et al. wasebenzisa uhlelo lwe-co-culture lwamaseli e-epithelial Caco-2 kanye ne-macrophage RAW264.7 ukuhlola umphumela wokulwa nokuvuvukala wezici zokudla, futhi imiphumela yabonisa ukuthi i-polysaccharide ye-S. japonicum ingakhuthaza ukukhiqizwa kwe-tumor necrosis factor.α ku-RAW264.7, ngaleyo ndlela kuvimbela ukubonakaliswa kwe-mRNA kwe-interleukin kumaseli e-Caco-2.

8. Thuthukisa izinga lesidoda

Ukuphathwa kwe-fucoidan kungathuthukisa ikhwalithi yesidoda kanye nenani ngokuthuthukisa ama-metabolites egazi kanye ne-microbiota yamathumbu. Abacwaningi bathola ukuthi ngemva kokuphathwa nge-polysaccharides yasolwandle, amazinga enkulumo yezakhi zofuzo ezihambisana ne-spermatogenesis anda kakhulu kumasende amagundane. Ngesikhathi esifanayo, kwakukhona ukuhlobana okuhle phakathi kwe-microbiota yamathumbu kanye nama-metabolites egazi. Ngokulawula kokubili, i-polysaccharide ye-fucoite ithuthukise i-metabolites ye-testis, yandisa ukuvikelwa kwe-antioxidant, futhi ilawula izinga lokukhuluma lezakhi zofuzo ezihlobene kumangqamuzana amagciwane, ngaleyo ndlela ibe nesandla ekuthuthukiseni isidoda kanye nokuthuthukiswa kwekhwalithi.