I-High Purity Metformin CAS 657-24-9 Umkhiqizi weMetformin
incazelo yomkhiqizo
I-Metformin: Umuthi onamandla wokwelapha isifo sikashukela
1. Iyini i-metformin?
Ama-Biguanides atholakala otshanini bembuzi (Galega Officinalis), isitshalo esisetshenziswe emithini yesintu amakhulu eminyaka. Isenzo semithi yesitshalo ngokwaso sincike ku-goatine (Isoamylene guanidine). I-Phenformin, i-Buformin, ne-metformin wonke akhiwe ngamakhemikhali futhi ahlanganisa ama-molecule amabili e-guanidine. I-Metformin iyisidakamizwa esithathwa ngomlomo esisetshenziswa kakhulu ekwelapheni isifo sikashukela sohlobo 2. Ingokwesigaba semithi ebizwa ngokuthi i-biguanides futhi ithathwa njengokwelashwa komugqa wokuqala kwesifo sikashukela.
2.Isebenza kanjani i-metformin?
Umsebenzi oyinhloko we-metformin ukwehlisa inani likashukela okhiqizwa isibindi futhi wenze amangqamuzana omzimba azwele kakhulu ku-insulin. Yehlisa ngempumelelo amazinga kashukela egazini futhi isiza ukulawula ukusabela komzimba ku-insulin.
I-Metformin ilawula ushukela wegazi ikakhulukazi ngokuvimbela ukuphuma kukashukela esibindi. I-Metformin incike kakhulu ku-organic cationic transporter 1(OCT 1) ukuze ingene ku-hepatocyte, bese ivimbela kancane iketango le-mitochondrial yokuphefumula eyinkimbinkimbi 1, okuholela ekwehleni kwe-ATP ye-intracellular kanye nokwenyuka kwamazinga e-AMP. Sonke siyazi ukuthi ukwehla kwe-ATP kanye nokwanda kwe-AMP kuseli kuzovimbela ngokuqondile i-gluconeogenesis futhi kunciphise ukuguqulwa kwe-glycerol ku-glucose.
Isilinganiso esikhulisiwe se-AMP/ATP esibangelwa i-metformin siphinde senze indlela yokusayina ye-AMPK isebenze, evimbela ukuhlanganiswa kwamafutha futhi ikhulise ukuzwela komzimba ku-insulin.
3. Yiziphi izinzuzo ze-metformin?
I-Metformin inikeza izinzuzo eziningi kubantu abanesifo sikashukela: +
I-1) Ukulawula ushukela wegazi: Ngokunciphisa ukukhiqizwa kukashukela esibindi nokuthuthukisa ukuzwela kwe-insulin, i-metformin isiza ukulawula amazinga kashukela egazini futhi iwavimbele ukuthi akhuphuke kakhulu noma aphansi kakhulu.
2) Ukulawulwa kwesisindo: I-Metformin imvamisa iholela ekwehleni kwesisindo esisesilinganisweni kubantu abanesifo sikashukela. Lokhu ikwenza ngokunciphisa isifiso sokudla, ikhulise imizwa yokusutha, futhi isize ukufaka i-glucose nezitolo zamafutha ukuze ithole amandla.
I-3) Ukuvikelwa Kwenhliziyo: Ucwaningo lubonisa ukuthi i-metformin inganciphisa ingozi yesifo senhliziyo, njengesifo senhliziyo nesifo sohlangothi, kubantu abanesifo sikashukela.
4) I-Polycystic ovary syndrome (PCOS): Ngaphezu kokwelapha isifo sikashukela, i-metformin isetshenziselwa ukwelapha i-PCOS, ukuphazamiseka kwehomoni okuthinta abesifazane. Kuyasiza ukulawula umjikelezo wokuya esikhathini, kunciphisa ukumelana ne-insulin, futhi kusize ekuvundeni.
4.Ingasetshenziswa kuphi i-metformin?
I-Metformin isetshenziswa kakhulu ekwelapheni isifo sikashukela sohlobo 2. Ingasetshenziswa iyodwa noma ihlanganiswe neminye imishanguzo yomlomo ye-antidiabetic noma ihlanganiswe nokwelashwa kwe-insulin, kuye ngezidingo zomuntu ngamunye. I-Metformin iboniswa ukuthi isetshenziswe kubantu abasanda kutholwa kanye nakubantu abanokulawula isikhathi eside kwesifo sikashukela. Kafushane, i-metformin iyisidakamizwa esinamandla esisetshenziswa kabanzi ekwelapheni isifo sikashukela sohlobo 2 kanye ne-PCOS. Inezinzuzo ezinjengokulawula ushukela wegazi, ukuphathwa kwesisindo, ukuvikelwa kwenhliziyo nemithambo yegazi, kanye nokukhululeka kwezimpawu ze-PCOS. Ngenxa yokuphumelela kwayo nokusetshenziswa kwayo yonke indawo, i-metformin isiphenduke ithuluzi elibalulekile ekusizeni abantu ukuba baphile impilo enempilo kuyilapho belawula kahle isimo sabo.
Ukudla
Ukuba mhlophe
Amaphilisi
Ukwakha Kwemisipha
Izithasiselo Zokudla
Iphrofayela Yenkampani
I-Newgreen iyibhizinisi elihamba phambili emkhakheni wezithasiselo zokudla, elasungulwa ngo-1996, elineminyaka engama-23 yesipiliyoni sokuthumela ngaphandle. Ngobuchwepheshe bayo bokukhiqiza bezinga lokuqala kanye neshabhu yokukhiqiza ezimele, inkampani isize ukuthuthukiswa komnotho emazweni amaningi. Namuhla, i-Newgreen iyaziqhenya ukwethula ukuqamba kwayo okusha - uhla olusha lwezithako zokudla ezisebenzisa ubuchwepheshe obuphezulu ukuthuthukisa ikhwalithi yokudla.
Kwa-Newgreen, ukusungula izinto ezintsha kungamandla aqhuba yonke into esiyenzayo. Ithimba lethu lochwepheshe lihlala lisebenzela ukuthuthukiswa kwemikhiqizo emisha nethuthukisiwe ukuthuthukisa ikhwalithi yokudla kuyilapho kugcinwa ukuphepha nempilo. Sikholelwa ukuthi ukusungula izinto ezintsha kungasisiza ukuthi sinqobe izinselele zomhlaba wanamuhla osheshayo futhi sithuthukise izinga lempilo yabantu emhlabeni wonke. Uhlu olusha lwezithasiselo luqinisekisiwe ukuthi luzohlangabezana nezindinganiso eziphakeme zamazwe ngamazwe, lunikeze amakhasimende ukuthula kwengqondo.Silwela ukwakha ibhizinisi elisimeme nelinenzuzo elingagcini nje ngokuletha ukuchuma kubasebenzi bethu nakubaninimasheya, kodwa futhi elifaka isandla emhlabeni ongcono wabo bonke.
I-Newgreen iyaziqhenya ukwethula ukwakheka kwayo kwakamuva kobuchwepheshe obuphezulu - umugqa omusha wezithasiselo zokudla ozothuthukisa ikhwalithi yokudla emhlabeni wonke. Sekuyisikhathi eside inkampani izibophezele ekusunguleni izinto ezintsha, ubuqotho, ukunqoba, kanye nokusebenzela impilo yabantu, futhi inguzakwethu othembekile embonini yokudla. Uma sibheka ikusasa, sijabule ngamathuba akhona kwezobuchwepheshe futhi sikholelwa ukuthi ithimba lethu lochwepheshe elizinikele lizoqhubeka nokuhlinzeka amakhasimende ethu ngemikhiqizo namasevisi aphambili.
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